Good performance of turquoise killifish (Nothobranchius furzeri) on pelleted diet as a step towards husbandry standardization

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A microinjection protocol for the generation of transgenic killifish (Species: Nothobranchius furzeri).

BACKGROUND A challenge in age research is the absence of short-lived vertebrate model organisms. The turquoise killifish Nothobranchius furzeri has an exceptionally short lifespan of 4-10 months depending on the strain. Thus, it possesses the shortest known maximum lifespan of a vertebrate species that can be bred in captivity. RESULTS Here we show the successful introduction of DNA and RNA m...

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Turquoise killifish

Reichard et al. introduce the turquoise killifish (Nothobranchius furzeri), notable for its short-life span and diapause stage.

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Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging

The African killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in captivity. N. furzeri comprises several wild-derived strains with striking differences in longevity ranging from 3 to 9 months, which makes it a powerful vertebrate model for aging research. The short life cycle of N. furzeri should also facilitate studies on adult traits that are specific to verte...

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Nothobranchius furzeri: A Model for Aging Research and More.

The short-lived killifish Nothobranchius furzeri inhabits ephemeral ponds in southeastern Africa and is characterized by rapid growth and early sexual maturation. With respect to the molecular, cellular, and integrative traits of aging, N. furzeri shows significant similarities to mammals, including humans. Recently, reference sequences for the N. furzeri genome have been published. Also, metho...

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Does Nothobranchius furzeri Gonarezhou die from a Parkinson’s-like Disease?

Neurodegeneration has diverse molecular causes. α-synucleinopathies are implicated in at least three neurodegenerative diseases: Parkinson’s Disease, Dementia with Lewy bodies and Multiple System Atrophy. Age-related increases in α-synuclein and its oligomers have been observed in short-lived Nothobranchius furzeri. N. furzeri Gonarezhou, with a lifespan of 9–12 weeks, is a new model organism f...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2020

ISSN: 2045-2322

DOI: 10.1038/s41598-020-65930-0